Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

نویسندگان

  • Colby Zaph
  • Yurong Du
  • Steven A. Saenz
  • Meera G. Nair
  • Jacqueline G. Perrigoue
  • Betsy C. Taylor
  • Amy E. Troy
  • Dmytro E. Kobuley
  • Robert A. Kastelein
  • Daniel J. Cua
  • Yimin Yu
  • David Artis
چکیده

Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4(+) T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 205  شماره 

صفحات  -

تاریخ انتشار 2008